| Date | Heure | Tour | Domicile | Score | Extérieur |
|---|---|---|---|---|---|
| 18.07.2015 | 05:00 | AMC | Club America | 0-1 | Manchester United |
| 22.07.2015 | 05:00 | AMC | Manchester United | 3-1 | San José Earthquakes |
| 25.07.2015 | 22:00 | AMC | Manchester United | 3-1 | FC Barcelone |
| 30.07.2015 | 03:00 | AMC | Manchester United | 0-2 | Paris Saint-Germain |
| 08.08.2015 | 13:45 | EPL J1 | Manchester United | 1-0 | Tottenham Hotspur |
| 14.08.2015 | 20:45 | EPL J2 | Aston Villa | 0-1 | Manchester United |
| 18.08.2015 | 20:45 | C1 | Manchester United | 3-1 | FC Bruges |
| 22.08.2015 | 13:45 | EPL J3 | Manchester United | 0-0 | Newcastle United |
| 26.08.2015 | 20:45 | C1 | FC Bruges | 0-4 | Manchester United |
| 30.08.2015 | 17:00 | EPL J4 | Swansea | 2-1 | Manchester United |
| 12.09.2015 | 18:30 | EPL J5 | Manchester United | 3-1 | Liverpool FC |
| 15.09.2015 | 20:45 | C1 T1 | PSV Eindhoven | 2-1 | Manchester United |
| 20.09.2015 | 17:00 | EPL J6 | Southampton FC | 2-3 | Manchester United |
| 23.09.2015 | 21:00 | COC 1/16 | Manchester United | 3-0 | Ipswich Town |
| 26.09.2015 | 16:00 | EPL J7 | Manchester United | 3-0 | Sunderland AFC |
| 30.09.2015 | 20:45 | C1 T1 | Manchester United | 2-1 | VfL Wolfsbourg |
| 04.10.2015 | 17:00 | EPL J8 | Arsenal FC | 3-0 | Manchester United |
| 17.10.2015 | 16:00 | EPL J9 | Everton FC | 0-3 | Manchester United |
| 21.10.2015 | 20:45 | C1 T1 | CSKA Moscou | 1-1 | Manchester United |
| 25.10.2015 | 15:05 | EPL J10 | Manchester United | 0-0 | Manchester City |
| 28.10.2015 | 21:00 | COC 1/8 | Manchester United | 0-0 (1-3 t.a.b.) | Middlesbrough |
| 31.10.2015 | 16:00 | EPL J11 | Crystal Palace | 0-0 | Manchester United |
| 03.11.2015 | 20:45 | C1 T1 | Manchester United | 1-0 | CSKA Moscou |
| 07.11.2015 | 16:00 | EPL J12 | Manchester United | 2-0 | West Bromwich |
| 21.11.2015 | 13:45 | EPL J13 | Watford | 1-2 | Manchester United |
| 25.11.2015 | 20:45 | C1 T1 | Manchester United | 0-0 | PSV Eindhoven |
| 28.11.2015 | 18:30 | EPL J14 | Leicester City | 1-1 | Manchester United |
| 05.12.2015 | 16:00 | EPL J15 | Manchester United | 0-0 | West Ham United |
| 08.12.2015 | 20:45 | C1 T1 | VfL Wolfsbourg | 3-2 | Manchester United |
| 12.12.2015 | 18:30 | EPL J16 | Bournemouth | 2-1 | Manchester United |
| 19.12.2015 | 16:00 | EPL J17 | Manchester United | 1-2 | Norwich City |
| 26.12.2015 | 13:45 | EPL J18 | Stoke City | 2-0 | Manchester United |
| 28.12.2015 | 18:30 | EPL J19 | Manchester United | 0-0 | Chelsea FC |
| 02.01.2016 | 16:00 | EPL J20 | Manchester United | 2-1 | Swansea |
| 09.01.2016 | 18:30 | CUP 1/32 | Manchester United | 1-0 | Sheffield United |
| 12.01.2016 | 20:45 | EPL J21 | Newcastle United | 3-3 | Manchester United |
| 17.01.2016 | 15:05 | EPL J22 | Liverpool FC | 0-1 | Manchester United |
| 23.01.2016 | 16:00 | EPL J23 | Manchester United | 0-1 | Southampton FC |
| 29.01.2016 | 20:55 | CUP 1/16 | Derby County | 1-3 | Manchester United |
| 02.02.2016 | 21:00 | EPL J24 | Manchester United | 3-0 | Stoke City |
| 07.02.2016 | 17:00 | EPL J25 | Chelsea FC | 1-1 | Manchester United |
| 13.02.2016 | 13:45 | EPL J26 | Sunderland AFC | 2-1 | Manchester United |
| 18.02.2016 | 19:00 | EL 1/16 | FC Midtjylland | 2-1 | Manchester United |
| 22.02.2016 | 20:45 | CUP 1/8 | Shrewsbury Town | 0-3 | Manchester United |
| 25.02.2016 | 21:05 | EL 1/16 | Manchester United | 5-1 | FC Midtjylland |
| 28.02.2016 | 15:05 | EPL J27 | Manchester United | 3-2 | Arsenal FC |
| 02.03.2016 | 21:00 | EPL J28 | Manchester United | 1-0 | Watford |
| 06.03.2016 | 17:00 | EPL J29 | West Bromwich | 1-0 | Manchester United |
| 10.03.2016 | 21:05 | EL 1/8 | Liverpool FC | 2-0 | Manchester United |
| 13.03.2016 | 17:00 | CUP 1/4 | Manchester United | 1-1 | West Ham United |
| 17.03.2016 | 21:05 | EL 1/8 | Manchester United | 1-1 | Liverpool FC |
| 20.03.2016 | 17:00 | EPL J31 | Manchester City | 0-1 | Manchester United |
| 03.04.2016 | 17:00 | EPL J32 | Manchester United | 1-0 | Everton FC |
| 10.04.2016 | 17:00 | EPL J33 | Tottenham Hotspur | 3-0 | Manchester United |
| 13.04.2016 | 20:00 | CUP 1/4 | West Ham United | 1-2 | Manchester United |
| 16.04.2016 | 16:00 | EPL J34 | Manchester United | 1-0 | Aston Villa |
| 20.04.2016 | 21:00 | EPL J30 | Manchester United | 2-0 | Crystal Palace |
| 23.04.2016 | 18:15 | CUP 1/2 | Everton FC | 1-2 | Manchester United |
| 01.05.2016 | 15:05 | EPL J36 | Manchester United | 1-1 | Leicester City |
| 07.05.2016 | 13:45 | EPL J37 | Norwich City | 0-1 | Manchester United |
| 10.05.2016 | 20:45 | EPL J35 | West Ham United | 3-2 | Manchester United |
| 17.05.2016 | 21:00 | EPL J38 | Manchester United | 3-1 | Bournemouth |
| 21.05.2016 | 18:30 | CUP F | Crystal Palace | 1-2 a.p. | Manchester United |
